Error-Prone DNA Polymerases
نویسندگان
چکیده
منابع مشابه
Error-prone repair DNA polymerases in prokaryotes and eukaryotes.
DNA repair is crucial to the well-being of all organisms from unicellular life forms to humans. A rich tapestry of mechanistic studies on DNA repair has emerged thanks to the recent discovery of Y-family DNA polymerases. Many Y-family members carry out aberrant DNA synthesis-poor replication accuracy, the favored formation of non-Watson-Crick base pairs, efficient mismatch extension, and most i...
متن کاملDNA polymerases ζ and Rev1 mediate error-prone bypass of non-B DNA structures
DNA polymerase ζ (Pol ζ) and Rev1 are key players in translesion DNA synthesis. The error-prone Pol ζ can also participate in replication of undamaged DNA when the normal replisome is impaired. Here we define the nature of the replication disturbances that trigger the recruitment of error-prone polymerases in the absence of DNA damage and describe the specific roles of Rev1 and Pol ζ in handlin...
متن کاملDNA polymerases f and Rev1 mediate error-prone bypass of non-B DNA structures
DNA polymerase f (Pol f) and Rev1 are key players in translesion DNA synthesis. The error-prone Pol f can also participate in replication of undamaged DNA when the normal replisome is impaired. Here we define the nature of the replication disturbances that trigger the recruitment of error-prone polymerases in the absence of DNA damage and describe the specific roles of Rev1 and Pol f in handlin...
متن کاملError-prone DNA polymerases: when making a mistake is the only way to get ahead.
Cells have high-fidelity polymerases whose task is to accurately replicate the genome, and low-fidelity polymerases with specialized functions. Although some of these low-fidelity polymerases are exceptional in their ability to replicate damaged DNA and restore the undamaged sequence, they are error prone on undamaged DNA. In fact, these error-prone polymerases are sometimes used in circumstanc...
متن کاملError-Prone DNA Polymerases Novel Structures and the Benefits of Infidelity
Studies on several recently discovered error-prone DNA polymerases reveal novel structures that may explain the low fidelity of this general class of enzymes, a number of which are involved in the replicative bypass (translesion synthesis) of base damage in DNA.
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ژورنال
عنوان ژورنال: Cell
سال: 2001
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(01)00509-8